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Shanghai Uhem Co.,Ltd
[China]

Address:
16G,T3 Gateway Plaza No.2601 Xietu Road,Shanghai China Shanghai 200030 China

Phone:
86-21-64260370

Contact name:
JACKY L , EXPORT MANAGER

Shanghai Uhem Co.,Ltd

Products

	Rapamycin (Sirolimus)

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Molecular formula : C51H79NO13
Molecular Weight : 914.2 g/mol
CAS:53123-88-9
Description :
Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins. Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway. Rapamycin name is derived from the native word for Easter Island, Rapi Nui.
Specifiation:
Appearance: White crystal powder
Purity (dry base): 97% - 102%
Water: 1.0% max.
Residue on ignition: 0.5% max.
Heavy metal: 20ppm max.
Solubility: Rapamycin is soluble in DMSO and Methanol